Have you ever wondered why hair grows on some parts of your body, but not others?
New research offers a possible explanation. Scientists found that hairless skin secretes a protein that blocks a signaling pathway (WNT) that controls hair growth.
Called Dickkopf 2 (DKK2), the protein is found in specific embryonic and adult tissues and has a variety of functions, the University of Pennsylvania researchers explained.
They found that plantar skin from mice — similar to the underside of the human wrist — had high levels of DKK2. When they genetically removed DKK2 from the mice, hair began to grow in this normally hairless skin region.
“This is significant because it tells us WNT is still present in hairless regions, it’s just being blocked,” said study co-senior author Sarah Millar, director of the Penn Skin Biology and Diseases Resource-Based Center.
“We know that WNT signaling is critical for the development of hair follicles; blocking it causes hairless skin, and switching it on causes formation of more hair,” Millar said in a Penn news release.
“In this study, we’ve shown the skin in hairless regions naturally produces an inhibitor that stops WNT from doing its job,” she added.
Hair follicles develop before birth. This means that hair follicles don’t regrow after severe burns or deep wounds. The researchers are currently investigating whether secreted WNT inhibitors suppress hair follicle development in such cases.
More than 80 million people in the United States have male- or female-pattern baldness, according to the American Academy of Dermatology. Previous research suggests that DKK2 may be associated with this condition, meaning it could be a potential target for treatment.
“We hope that these lines of investigation will reveal new ways to improve wound healing and hair growth, and we plan to continue to pursue these goals moving forward,” Millar said.
The study was published Nov. 28 in the journal Cell Reports.
November 30, 2018
August 31, 2018
The golden combination of self or shared indulgence
#1 Use lube!
It is true that wetter is better, so grab some lube to increase slide and reduce friction. Just check the ingredients to make sure there are no nasty sugars in there that may cause a yeast infection. According to sexperts, using lube can make your hand job 100% better.
#2 Use a clitoral vibrator
Once you’re wet, an external vibrator will help to awaken all the external hotspots like your clitoris. This will encourage circulation, making you extra-sensitive, and will get the erectile tissue in your clitoris working, making it bigger and easier to find. Using lube and a clitoral vibrator will make your hand jobs 200% better. A vibrator, like the Magic Bullet, is perfect, as the tapered tip allows for pinpoint accuracy.
#3 Use a dildo
Dildos are amazing for reaching internal hotspots that are much harder to get to with your hands, such as the G-spot, A-spot and C-Spot. Just make sure you warm up first using your fingers and use plenty of lube for the comfiest and most pleasurable experience. The combo of a dildo, a clit vibrator and lube can make your hand jobs 300% better. Give it a go with the G-spot dildo that’s angled to hit your G-spot, and has a suction base so you can go hands-free.
#4 Use a butt plug
Using a butt plug during masturbation can enhance sensations in a number of ways. Not only does it offer a secondary point of stimulation, which can enhance pleasure and speed up orgasms, but it’s a hands-free way to help angle your dildo towards your G-spot. If you can believe it, using a butt plug with a dildo, clit vibrator and lube can make your clitoris hand jobs 400% better! Start with a beginner’s butt plug that’s small and comfy to insert, but still packs a punch when it comes to anal stimulation.
#5 Use nipple clamps
A lot of people neglect their nipple during masturbation, which is a shame because playing with nipples can produce oxytocin (a hormone that plays a big part in achieving orgasm). Simply, if you aren’t producing it, you aren’t going to orgasm. Not only do nipple clamps add sensation while you wear them, but when you take them off, you will get a rush of blood to the area that will make your nipples even more responsive to touch.
This golden combination of lube, a clit vibrator, a dildo, with a butt plug and nipple clamps can make your hand jobs lot better - or at the very least, can help to make your next solo or shared masturbation session the best yet.
It is true that wetter is better, so grab some lube to increase slide and reduce friction. Just check the ingredients to make sure there are no nasty sugars in there that may cause a yeast infection. According to sexperts, using lube can make your hand job 100% better.
#2 Use a clitoral vibrator
Once you’re wet, an external vibrator will help to awaken all the external hotspots like your clitoris. This will encourage circulation, making you extra-sensitive, and will get the erectile tissue in your clitoris working, making it bigger and easier to find. Using lube and a clitoral vibrator will make your hand jobs 200% better. A vibrator, like the Magic Bullet, is perfect, as the tapered tip allows for pinpoint accuracy.
#3 Use a dildo
Dildos are amazing for reaching internal hotspots that are much harder to get to with your hands, such as the G-spot, A-spot and C-Spot. Just make sure you warm up first using your fingers and use plenty of lube for the comfiest and most pleasurable experience. The combo of a dildo, a clit vibrator and lube can make your hand jobs 300% better. Give it a go with the G-spot dildo that’s angled to hit your G-spot, and has a suction base so you can go hands-free.
#4 Use a butt plug
Using a butt plug during masturbation can enhance sensations in a number of ways. Not only does it offer a secondary point of stimulation, which can enhance pleasure and speed up orgasms, but it’s a hands-free way to help angle your dildo towards your G-spot. If you can believe it, using a butt plug with a dildo, clit vibrator and lube can make your clitoris hand jobs 400% better! Start with a beginner’s butt plug that’s small and comfy to insert, but still packs a punch when it comes to anal stimulation.
#5 Use nipple clamps
A lot of people neglect their nipple during masturbation, which is a shame because playing with nipples can produce oxytocin (a hormone that plays a big part in achieving orgasm). Simply, if you aren’t producing it, you aren’t going to orgasm. Not only do nipple clamps add sensation while you wear them, but when you take them off, you will get a rush of blood to the area that will make your nipples even more responsive to touch.
This golden combination of lube, a clit vibrator, a dildo, with a butt plug and nipple clamps can make your hand jobs lot better - or at the very least, can help to make your next solo or shared masturbation session the best yet.
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